salA [Thu Oct 13 2016 18:19:35 GMT+0200 (CEST)]

negative regulator of scoC expression

locus: BSU01540

pI: 5.00

mw: 38.00 kDa

function: control of alkaline protease expression

product: MRP family regulator

essential: no

synonyms: ybaL

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.7|Control of transcription factor (other than two-component system)]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.6|Transition state regulators]

[SW|Categories] containing this gene/protein

• [SW|transcription factors and their control], [SW|transition state regulators]

This gene is a member of the following [SW|regulons]

• [SW|SalA regulon]

Gene

Coordinates on the chromosome (coding sequence): 157,421 -> 158,479

Phenotypes of a mutant

• increased expression of ''[protein|search|aprE]'' (due to loss of repression of ''[protein|search|scoC]'' expression)

The protein

Catalyzed reaction/ biological activity

• transcription repression of ''[protein|search|scoC]'' expression [SW|26094643]

Protein family

• Mrp/NBP35 ATP-binding proteins family (according to Swiss-Prot)

[SW|Domains]

• DNA-binding domain: aa 1 - 60 [Pubmed|26094643]
• ATP-binding Walker domain: aa 105 - 275 [Pubmed|26094643]
• domain for the interaction with [SW|PtkA]: aa 294 - 352

Modification

• [SW|PtkA]-dependent phosphorylation at Tyr-327 results in better binding of the target promoter [Pubmed|26094643]

[SW|Interactions]

• [SW|SalA]-[SW|PtkA], for phosphorylation of [SW|SalA] [Pubmed|26094643]

Expression and Regulation

Regulation

• negative autoregulation

Biological materials

Mutant

• 1A919 ( ''salA''::''erm''), [Pubmed|15126467], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A919&Search=1A919 BGSC]

References

• 15126467,26286503,26094643