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salA [Thu Oct 13 2016 18:19:35 GMT+0200 (CEST)]
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salA [Thu Oct 13 2016 18:19:35 GMT+0200 (CEST)]

negative regulator of scoC expression
Locus
BSU01540
Isoelectric point
5.00
Molecular weight
38.00 kDa
Function
control of alkaline protease expression
Product
MRP family regulator
Essential
no
Synonyms
ybaL
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Regulation of gene expression → Transcription factors and their control → Control of transcription factor (other than two-component system)
  • Information processing → Regulation of gene expression → Transition state regulators

    • Categories containing this gene/protein

  • transcription factors and their control, transition state regulators

    • This gene is a member of the following regulons

  • SalA regulon

    • Gene

    Coordinates on the chromosome (coding sequence)
    157,421 -> 158,479

    Phenotypes of a mutant

  • increased expression of aprE (due to loss of repression of scoC expression)

    • The protein

    Catalyzed reaction/ biological activity

  • transcription repression of scoC expression 26094643

    • Protein family

  • Mrp/NBP35 ATP-binding proteins family (according to Swiss-Prot)

    • Domains

  • DNA-binding domain: aa 1 - 60 PubMed
  • ATP-binding Walker domain: aa 105 - 275 PubMed
  • domain for the interaction with PtkA: aa 294 - 352

    • Modification

  • PtkA-dependent phosphorylation at Tyr-327 results in better binding of the target promoter PubMed

    • Interactions

  • SalA-PtkA, for phosphorylation of SalA PubMed

    • Expression and Regulation

    Regulation

  • negative autoregulation

    • Biological materials

    Mutant

  • 1A919 ( salA::erm), PubMed, available at BGSC

    • References

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