thiO [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

FAD-dependent glycine oxidase

Locus: BSU11670

Isoelectric point: 5.90

Molecular weight: 40.00 kDa

Function: biosynthesis of thiamine

Product: glycine oxidase

Essential: no

E.C.: 1.4.3.19

Synonyms: goxB, yjbR

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis/ acquisition of thiamine

Categories containing this gene/protein

• biosynthesis of cofactors

This gene is a member of the following regulons

• Thi-box

Gene

Coordinates on the chromosome (coding sequence): 1,243,735 -> 1,244,844

The protein

Catalyzed reaction/ biological activity

• Glycine + H₂O + O₂ = glyoxylate + NH₃ + H₂O₂ (according to Swiss-Prot)

Protein family

• DAMOX/DASOX family (according to Swiss-Prot)

Modification

• FAD PubMed

Structure

• 1NG3 (complex with acetyl-glycine), 1RYI

Localization

• cytoplasm (according to Swiss-Prot)

Interactions

• the FAD-containing holoenzyme is a homotetramer PubMed

Expression and Regulation

Operon

• tenA-tenI-thiO-thiS-thiG-thiF-thiD PubMed

Regulation

• repressed by thiamine (Thi-box) PubMed

Regulatory mechanism

• Thi-box: RNA switch PubMed

References

Reviews

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Original publications

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