adaptor protein for ClpX-ClpP-catalyzed Spx degradation, confers resistance against nitrosating agents
function
stimulation of Spx degradation
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.4|Additional proteins involved in proteolysis][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.10|Resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)][SW|Categories] containing this gene/protein
[SW|proteolysis], [SW|resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)]Gene
Coordinates on the chromosome (coding sequence)
1,233,614 -> 1,234,513
Phenotypes of a mutant
increased thermotolerance due to increased stabiliy of [protein|search|Spx] and thus increased expression of ''[protein|search|trxA]'' [Pubmed|24417481]The protein
Catalyzed reaction/ biological activity
adaptor protein for [protein|search|ClpX]-[protein|search|ClpP]-catalyzed [protein|search|Spx] degradation [Pubmed|19074380]Protein family
UPF0413 family (according to Swiss-Prot)[SW|Cofactors]
contains Zn atoms (coordinated by the N-terminal His-rich region) [Pubmed|19074380]Effectors of protein activity
[protein|search|YjbH] aggregates under stress conditions, resulting in the inability to bind to [protein|search|Spx], and therefore in stabilization of [protein|search|Spx] [Pubmed|25353645]Zn atom is released upon treatment with strong oxidants [Pubmed|19074380]interaction with [protein|search|YirB] inhibits the formation of a complex with [protein|search|Spx] [Pubmed|21378193][SW|Localization]
cytosolic protein[SW|Interactions]
[protein|search|YjbH]-[protein|search|Spx] [Pubmed|19074380][protein|search|YirB]-[protein|search|YjbH] [Pubmed|21378193]Expression and Regulation
Operon
''[protein|search|yjbI]-[protein|search|yjbH]'' [Pubmed|17293416]Additional information
A [protein|search|ncRNA] is predicted between '[protein|search|yizD]' and '[protein|search|yjbH]' [PubMed|20525796]Biological materials
Mutant
BKE11550 (''[protein|search|yjbH]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab)Labs working on this gene/protein
[SW|Peter Zuber], Oregon Health and Science University, USA[http://www.ogi.edu/people/dsp_person.cfm?person_id=411D6801-2A56-D16D-58A06B4480EDB9C7 Homepage][SW|Claes von Wachenfeldt], Lund University, Sweden [http://aron.ldc.lu.se/kundwebb/cellorg/mibiol/research/wachen/index.htm Homepage]References
Reviews
23375660,23479438,19609260 Original Publications
17293416,19074380,17908206,20525796,21378193,21947404,24417481,24942655,25353645,27191337 
