capB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

capsular polyglutamate biosynthesis

locus: BSU35900

pI: 5.00

mw: 43.00 kDa

function: capsule synthesis

product: poly-gamma-glutamate synthetase

essential: no

synonyms: ywsC, pgsB

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.4|Capsule biosynthesis and degradation]

[SW|Categories] containing this gene/protein

• [SW|capsule biosynthesis and degradation]

This gene is a member of the following [SW|regulons]

• [SW|DegU regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,699,446 -> 3,700,627

Phenotypes of a mutant

• no synthesis of the poly-gamma-glutamate capsule [Pubmed|11751809]

The protein

Catalyzed reaction/ biological activity

• synthesis of poly-gamma-glutamate from L-Glu [Pubmed|11751809]

Expression and Regulation

Operon

• ''[protein|search|capB]-[protein|search|capC]-[protein|search|capA]-[protein|search|capE]'' [Pubmed|11751809]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|19420703]

Regulatory mechanism

• [protein|search|DegU]-P: transcription activation [Pubmed|19734658]

Additional information

• The operon is not expressed in the lab strain 168 due to lack of expression of [protein|search|DegQ] resulting in inactivity of [protein|search|DegS] and [protein|search|DegU] [PubMed|21965392]
• expression of the operon is reduced in '[protein|search|motA]' or '[protein|search|motB]' mutants due to reduced [protein|search|DegU] phosphorylation [PubMed|24296669]

References

Reviews

• 20735481,16689787

Original publications

• 11751809,19420703,19389763,16233197,19734658,20564357,20564574,24296669,21965392,27073802