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pabC [2017-8-11 16:0:3]
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pabC [2017-8-11 16:0:3]

aminodeoxychorismate lyase
Locus
BSU00760
Isoelectric point
6.12
Molecular weight
33.36 kDa
Protein length
293 aa Sequence Blast
Gene length
879 bp Sequence Blast
Function
biosynthesis of folate
Product
aminodeoxychorismate lyase
Essential
no
E.C.
4.1.3.38
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of folate

    • Gene

    Coordinates
    84,874 → 85,755

    The protein

    Catalyzed reaction/ biological activity

  • 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate (according to Swiss-Prot)

    • Protein family

  • class-IV pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)

    • Structure

  • 4WHX (from B. pseudomallus, 27% identity)

    • Expression and Regulation

    Operons

    Genes
    pabB-pabA-pabC-sul-folB-folK-yazB-yacF-lysS
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulation

  • translation repressed by tryptophan (MtrB) PubMed
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    Additional information

  • the pabA-pabC part of the mRNA is substantially stabilized upon depletion of RNase Y PubMed

    • References

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