pabC [Tue Feb 09 2016 20:14:15 GMT+0100 (CET)]

aminodeoxychorismate lyase

locus: BSU00760

pI: 6.00

mw: 33.00 kDa

function: biosynthesis of folate

product: aminodeoxychorismate lyase

essential: no

ec: 4.1.3.38

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

Gene

Coordinates on the chromosome (coding sequence): 84,874 -> 85,755

The protein

Catalyzed reaction/ biological activity

• 4-amino-4-deoxychorismate = 4-aminobenzoate pyruvate (according to Swiss-Prot)

Protein family

• class-IV pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|pabB]-[protein|search|pabA]-[protein|search|pabC]-[protein|search|sul]-[protein|search|folB]-[protein|search|folK]-[protein|search|yazB]-[protein|search|yacF]-[protein|search|lysS]'' [Pubmed|9084182]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9084182]

Additional information

• the '[protein|search|pabA]-[protein|search|pabC]' part of the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]

References

• 9084182,21815947