glycerol-3-phosphate cytidylyltransferase
function
biosynthesis of teichoic acid
product
glycerol-3-phosphate cytidylyltransferase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|PhoP regulon], [SW|WalR regulon]Gene
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol (according to Swiss-Prot)Protein family
cytidylyltransferase family (according to Swiss-Prot)Structure
[PDB|1N1D] (complex with CDP-glycerol) [Pubmed|10508782], [PDB|1COZ][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|TagD]-[protein|search|TagD] [Pubmed|10508782]Expression and Regulation
Operon
''[protein|search|tagD]-[protein|search|tagE]-[protein|search|tagF]-[protein|search|tagG]-[protein|search|tagH]'' [Pubmed|22383849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7581998]Regulation
repressed by phosphate ([protein|search|PhoP]) [Pubmed|9457886]Regulatory mechanism
[protein|search|PhoP]: transcription repression [Pubmed|9457886][protein|search|WalR]: transcription activation [Pubmed|12950927]References
Reviews
Original publications
9683503,9457886,11673441,10508782,2507871,12950927,7581998,20525796,22383849 
