cmpA [Tue May 31 2016 20:05:01 GMT+0200 (CEST)]

cortex morphogenic protein A, checkpoint protein, orchestrates spore coat and cortex morphogenesis

Locus: G8J2-20

Isoelectric point: 0.00

Molecular weight: 4.00 kDa

Function: represses cortex assembly until the successful initiation of spore coat assembly

Product: cortex morphogenic protein A, adapter protein targeting SpoIVA for degradation by ClpXP upon spore envelope defects

Synonyms

Genomic Context

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Categories containing this gene/protein

• Lifestyles → Sporulation → Sporulation proteins → Spore coat proteins → Not yet assigned

Categories containing this gene/protein

• sporulation proteins

This gene is a member of the following regulons

• SigE regulon, SpoIIID regulon

Gene

Coordinates on the chromosome (coding sequence): 525,021 -> 528,076

Phenotypes of a mutant

• quicker progressing through the sporulation cycle PubMed
• overexpression of CmpA results in heat-sensitive sporulation PubMed, this can be suppressed by mutations in clpP and clpX PubMed

Protein

Catalyzed reaction/ biological activity

• orchestrates spore coat and cortex assembly PubMed
• represses cortex assembly until spore coat assembly successfully initiates PubMed

Localization

• surface of the developing spore, this depends on a functional SpoIVA PubMed

Interactions

• ClpX-CmpA (for ClpX-ClpP-dependent degradation of SpoIVA) PubMed
• CmpA-SpoIVA (for ClpX-ClpP-dependent degradation of SpoIVA) PubMed

Expression and Regulation

Operon

• cmpA PubMed

Sigma factor

• SigE PubMed

Regulation

• expressed in mother cell during sporulation (SigE, SpoIIID) PubMed

Regulatory mechanism

• SpoIIID: transcription activation PubMed

References

Reviews

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Original publications

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