carboxy-terminal processing serine protease, cleaves SpoIVFA, this results in processing of pro-SigK
function
control of SigK activation
product
carboxy-terminal processing serine protease,
cleaves SpoIVFA
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.4|Additional proteins involved in proteolysis][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][SW|Categories] containing this gene/protein
[SW|proteolysis], [SW|sigma factors and their control], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|SigE regulon], [SW|SigG regulon]Gene
Coordinates on the chromosome (coding sequence)
3,622,356 -> 3,623,798
The protein
Protein family
PDZ protease [Pubmed|24243021]Paralogous protein(s)
[protein|search|CtpA]Effectors of protein activity
substrate binding of CtpB induces opening of the PDZ gate and protease activation [Pubmed|24243021][protein|search|CtpB] acts in concert with a second signaling protease, [SW|SpoIVB] [Pubmed|24243021]Structure
[PDB|4C2C] [Pubmed|24243021]forms a ring-like scaffold with two narrow tunnels for substrate binding [Pubmed|24243021][SW|Localization]
intracellular space between the mother cell and the forespore [Pubmed|24243021][SW|Interactions]
forms a dimeric ring [Pubmed|24243021][protein|search|CtpB]-[SW|SpoIVFA] [Pubmed|24243021]Expression and Regulation
Operon
''ctpB'' (according to [http://dbtbs.hgc.jp/COG/prom/ctpB.html DBTBS])[SW|Sigma factor]
[protein|search|SigE] [Pubmed|15699190], [protein|search|SigG] [Pubmed|15699190,16497325]Regulation
expressed during sporulation ([protein|search|SigE], [protein|search|SigG]) [Pubmed|15699190,16497325]Biological materials
Mutant
1S129 ( ''ctpB''::''tet''), [Pubmed|14526016], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S129&Search=1S129 BGSC]References
14526016,17557826,16818230,15699190,16497325,24243021 
