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pksR [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]
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pksR [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

polyketide synthase
locus
BSU17220
pI
5.00
mw
284.00 kDa
function
polyketide synthesis
product
polyketide synthase
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]
  • [SW|Categories] containing this gene/protein

  • [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]
  • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|CodY regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,850,890 -> 1,858,521

    The protein

    Structure

  • [PDB|4U3V] (enoyl-isomerase domain, aa 1124-1395) [Pubmed|25089587]
  • Expression and Regulation

    Operon

  • ''[protein|search|pksC]-[protein|search|pksD]-[protein|search|pksE]-[protein|search|acpK]-[protein|search|pksF]-[protein|search|pksG]-[protein|search|pksH]-[protein|search|pksI]-[protein|search|pksJ]-[protein|search|pksL]-[protein|search|pksM]-[protein|search|pksN]-[protein|search|pksR]'' [Pubmed|22383849]
  • Regulation

  • expressed during the transition from growth to stationary phase ([protein|search|AbrB], [protein|search|CodY]) [Pubmed|24187085]
  • Regulatory mechanism

  • [protein|search|AbrB]: transcription repression [Pubmed|24187085]
  • [protein|search|CodY]: transcription activation [Pubmed|24187085]
  • References

  • 10960106,25089587,17190806,22383849,24187085