pksR [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

polyketide synthase

locus: BSU17220

pI: 5.00

mw: 284.00 kDa

function: polyketide synthesis

product: polyketide synthase

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]

[SW|Categories] containing this gene/protein

• [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon], [SW|CodY regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,850,890 -> 1,858,521

The protein

Structure

• [PDB|4U3V] (enoyl-isomerase domain, aa 1124-1395) [Pubmed|25089587]

Expression and Regulation

Operon

• ''[protein|search|pksC]-[protein|search|pksD]-[protein|search|pksE]-[protein|search|acpK]-[protein|search|pksF]-[protein|search|pksG]-[protein|search|pksH]-[protein|search|pksI]-[protein|search|pksJ]-[protein|search|pksL]-[protein|search|pksM]-[protein|search|pksN]-[protein|search|pksR]'' [Pubmed|22383849]

Regulation

• expressed during the transition from growth to stationary phase ([protein|search|AbrB], [protein|search|CodY]) [Pubmed|24187085]

Regulatory mechanism

• [protein|search|AbrB]: transcription repression [Pubmed|24187085]
• [protein|search|CodY]: transcription activation [Pubmed|24187085]

References

• 10960106,25089587,17190806,22383849,24187085