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fhuD [2017-11-16 15:27:27]
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fhuD [2017-11-16 15:27:27]

hydroxamate siderophore ABC transporter (only ferrichrome) (binding protein)
locus
BSU33320
pI
9.16
mw
34.27 kDa
protein length
315 aa Sequence Blast
gene length
945 bp Sequence Blast
function
siderophore uptake
product
hydroxamate siderophore ABC transporter (only ferrichrome) (binding protein)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

    • Gene

    Coordinates
    3,418,474 → 3,419,421

    Phenotypes of a mutant

  • poor growth with the xenosiderophore ferrichrome as single source of iron [Pubmed|23220087]

    • The protein

    Protein family

  • bacterial solute-binding protein 8 family (according to Swiss-Prot)

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot), extracellular (signal peptide) [Pubmed|18957862]

    • Expression and Regulation

    Operons

    genes
    [gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]
    description
    [Pubmed|22383849]

    regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]

    • regulation

  • induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [Pubmed|29133393,12354229]
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    Biological materials

    Mutant

  • BKE33320 (Δ[gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCTCATACCTTCTTTC, downstream forward: _UP4_TAAACAAAAGAGCCGCCTGC
  • BKK33320 (Δ[gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33320 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATCTCATACCTTCTTTC, downstream forward: _UP4_TAAACAAAAGAGCCGCCTGC

    • References

  • 10092453,16672620,12354229,18957862,23220087