fhuD [2017-8-11 16:0:3]

hydroxamate siderophore ABC transporter (only ferrichrome) (binding protein)

locus: BSU33320

pI: 9.16

mw: 34.27 kDa

protein length: 315 aa

gene length: 945 bp

function: siderophore uptake

product: hydroxamate siderophore ABC transporter (only ferrichrome) (binding protein)

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
• [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

Gene

Coordinates: 3,418,474 → 3,419,421

Phenotypes of a mutant

• poor growth with the xenosiderophore ferrichrome as single source of iron [Pubmed|23220087]

The protein

Protein family

• bacterial solute-binding protein 8 family (according to Swiss-Prot)

[SW|Localization]

• cell membrane (according to Swiss-Prot), extracellular (signal peptide) [Pubmed|18957862]

Expression and Regulation

Operons

• genes: [gene|84CC89907EF39770F5BFACA82A11B04CF76EC5AA|fhuD]
  description: [Pubmed|22383849]

  regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]

  regulation

  • induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [Pubmed|29133393,12354229]

References

• 10092453,16672620,12354229,18957862,23220087