function
antagonist of PrkC-dependent phosphorylation
product
protein phosphatase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases][SW|Categories] containing this gene/protein
[SW|protein modification], [SW|sporulation/ other]Gene
Coordinates on the chromosome (coding sequence)
1,650,384 -> 1,651,148
Phenotypes of a mutant
A ''prpC'' mutant is less lytic in late stationary phase. [Pubmed|12399479]inactivation of ''[SW|prpC]'' reduces sporulation efficiency to 50.7% that of wild type cells [Pubmed|26735940]The protein
Catalyzed reaction/ biological activity
dephosphorylation of [tufA|search|EF-tu]-Thr63-P [Pubmed|26056311][SW|Cofactors]
divalent cations such as magnesium or manganeseEffectors of protein activity
inhibited by inorganic phosphate and glycero-2-phosphate [Pubmed|16857667]Structure
[PDB|1TXO] (from ''Mycobacterium tuberculosis'', 34% identity, 54% similarity) [Pubmed|15530359][SW|Interactions]
[protein|search|YvcK]-[protein|search|PrpC] [Pubmed|25012659][protein|search|PrpC]-[tufA|search|EF-tu] [Pubmed|26056311]Expression and Regulation
Operon
''[protein|search|prpC]-[protein|search|prkC]-[protein|search|cpgA]'' [Pubmed|16025310]Biological materials
Mutant
OMG401 (aphA3), available in the [SW|Stülke] lab1A962 (no resistance), [Pubmed|12399479], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A962&Search=1A962 BGSC]1A964 (no resistance), [Pubmed|12399479], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A964&Search=1A964 BGSC]References
Reviews
Original publications
19246764,10986276,17693724,12399479,18757537,15530359,23793375,16025310,24390483,25012659,26056311,26735940,27806131 
