truA [Mon Jan 18 2016 18:34:34 GMT+0100 (CET)]

pseudouridylate synthase I, universally conserved protein

locus: BSU01480

pI: 6.00

mw: 27.00 kDa

function: tRNA modification

product: pseudouridylate synthase I

essential: no

ec: 5.4.99.12

synonyms: ybaH

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
• [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]

[SW|Categories] containing this gene/protein

• [SW|translation], [SW|universally conserved proteins]

This gene is a member of the following [SW|regulons]

• [SW|stringent response]

Gene

Coordinates on the chromosome (coding sequence): 152,937 -> 153,680

The protein

Catalyzed reaction/ biological activity

• tRNA uridine = tRNA pseudouridine (according to Swiss-Prot)

Protein family

• tRNA pseudouridine synthase truA family (according to Swiss-Prot)

Structure

• [PDB|1VS3] (from ''Thermus thermophilus'', 43% identity)

Additional information

• [SW|universally conserved protein]

Expression and Regulation

Regulation

• [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

References

• 11948165