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kdgA [2018-11-23 17:02:09]
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kdgA [2018-11-23 17:02:09]

2-dehydro-3-deoxy-phosphogluconate aldolase
Locus
BSU22100
Isoelectric point
5.27
Molecular weight
20.72 kDa
Protein length
196 aa Sequence Blast
Gene length
588 bp Sequence Blast
Function
utilization of galacturonic acid
Product
2-dehydro-3-deoxy-phosphogluconate aldolase
Essential
no
E.C.
4.1.3.16
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of hexuronate

    • Gene

    Coordinates
    2,323,009 → 2,323,599

    The protein

    Catalyzed reaction/ biological activity

  • 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate (according to Swiss-Prot)

    • Structure

  • 1VLW (from Thermotoga maritima, 41% identity)

    • Localization

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    kdgR-kdgK-kdgA-kdgT
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • KdgR: repression, PubMed, in KdgR regulon
  • CcpA: repression, PubMed, in CcpA regulon

    • Regulation

  • induced by galacturonate (KdgR) PubMed
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    Biological materials

    Mutant

  • BKE22100 (ΔkdgA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GTTTTCAACGACTTTGGACT, downstream forward: _UP4_TAAGTGGAATTGTTTTTTCA
  • BKK22100 (ΔkdgA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GTTTTCAACGACTTTGGACT, downstream forward: _UP4_TAAGTGGAATTGTTTTTTCA

    • References

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