kdgA [Mon Aug 31 2015 13:55:12 GMT+0200 (CEST)]

2-dehydro-3-deoxy-phosphogluconate aldolase

locus: BSU22100

pI: 5.27

mw: 20.00 kDa

function: utilization of galacturonic acid

product: 2-dehydro-3-deoxy-phosphogluconate aldolase

essential: no

ec: 4.1.3.16

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.15|Utilization of hexuronate]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|KdgR regulon]

The protein

Catalyzed reaction/ biological activity

• 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate (according to Swiss-Prot)

Protein family

• anti-sigma-factor family (according to Swiss-Prot)

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|kdgR]-[protein|search|kdgK]-[protein|search|kdgA]-[protein|search|kdgT]'' [Pubmed|9846747]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9846747]

Regulation

• induced by galacturonate ([protein|search|KdgR]) [Pubmed|9846747]
• repressed by glucose ([protein|search|CcpA]) [Pubmed|9846747]

Regulatory mechanism

• [protein|search|KdgR]: transcription repression [Pubmed|9846747]
• [protein|search|CcpA]: transcription repression [Pubmed|9846747]

References

• 9846747