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sdpC [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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sdpC [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

toxin, collapses the proton motive force and induces autolysis, kills non-sporulating cells, induces activity of SigW
locus
BSU33770
pI
9.00
mw
22.00 kDa
function
killing of non-sporulating sister cells
product
toxin, kills non-sporulating cells
essential
no
synonyms
yvaY
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.3|Toxins, antitoxins and immunity/ Additional genes]

    • [SW|Categories] containing this gene/protein

  • [SW|toxins, antitoxins and immunity against toxins]

    • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|Rok regulon], [SW|Spo0A regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,465,776 -> 3,466,387

    The protein

    Catalyzed reaction/ biological activity

  • toxin, collapses the proton motive force and induces autolysis [Pubmed|22469514]

    • Modification

  • the mature SDP is a 42-residue peptide with one disulfide bridge [Pubmed|20805502]

    • [SW|Localization]

  • secreted (according to Swiss-Prot)

    • [SW|Interactions]

  • [protein|search|CsaA]-[protein|search|SdpC] [Pubmed|13129613]

    • Expression and Regulation

    Operon

  • ''[protein|search|sdpA]-[protein|search|sdpB]-[protein|search|sdpC]'' [Pubmed|12817086]

    • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • expressed under conditions that trigger sporulation ([SW|Spo0A]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647,15687200 PubMed]
  • repressed by [protein|search|Rok] [Pubmed|15743949]
  • repressed during logrithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]

    • Regulatory mechanism

  • [SW|Spo0A]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647,15687200 PubMed]
  • [protein|search|Rok]: transcription repression [Pubmed|15743949]
  • [protein|search|AbrB]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]

    • Additional information

  • the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] [PubMed|21815947]

    • References

    Reviews

  • 20955377

    • Original Publications

  • 12817086,16469701,16629676,13129613,14651647,15687200,15743949,15687200,17720793,12107147,22469514,20805502,23687264,21815947