dtpT [Sat Jun 25 2016 16:57:30 GMT+0200 (CEST)]

proton-dependent di- and tripeptide transporter

locus: BSU03670

pI: 9.00

mw: 53.00 kDa

function: uptake of di- and tripeptides

product: peptide transporter

essential: no

synonyms: yclF

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.2|Peptide transporter]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.4|Utilization of peptides]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|utilization of nitrogen sources other than amino acids], [SW|membrane proteins], [SW|sporulation proteins]

This gene is a member of the following [SW|regulons]

• [SW|ScoC regulon], [SW|TnrA regulon]

Gene

Coordinates on the chromosome (coding sequence): 416,235 -> 417,713

The protein

Protein family

• POT family of secondary (PMF-dependent) transporters

Structure

• [PDB|4IKV], the protein from ''Geobacillus kaustophilus'' (65% identity, 87% similarity), [Pubmed|23798427]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|dtpT]'' [Pubmed|22383849]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|25966844]

Regulation

• repressed during exponential growth ([protein|search|ScoC]) [Pubmed|25966844,11717292]
• [protein|search|TnrA]: transcription activation [Pubmed|25755103]

Regulatory mechanism

• [protein|search|ScoC]: transcription repression [Pubmed|25966844,11717292]

References

• 11717292,8458848,23798427,25966844,25755103