surfactin synthetase / competence
function
antibiotic synthesis
product
surfactin synthetase / competence
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|Abh regulon], [SW|CodY regulon], [SW|ComA regulon], [SW|PerR regulon], [SW|PhoP regulon], [SW|Spx regulon]Gene
Coordinates on the chromosome (coding sequence)
376,968 -> 387,731
Phenotypes of a mutant
altered cell death pattern in colonies [Pubmed|23012477]reduced swarming of srfAA mutant of ''B. subtilis'' NCIB3610 [Pubmed|15066026]The protein
Protein family
ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)Modification
phosphorylation on Ser-1006 [Pubmed|17218307][SW|Localization]
membrane [Pubmed|18763711]Expression and Regulation
Operon
''[SW|srfAA]-[SW|srfAB]-[protein|search|comS]-[SW|srfAC]-[SW|srfAD]'' [Pubmed|1715856][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1715856]Regulation
repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8830686]repressed during hydrogen peroxide stress ([protein|search|PerR]) [Pubmed|16166527]expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]induced under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|25666134]Regulatory mechanism
[protein|search|PhoP]: transcription activation [Pubmed|25666134][protein|search|CodY]: transcription repression [Pubmed|8830686][protein|search|ComA]: transcription activation [Pubmed|1715856,16091051][protein|search|PerR]: transcription activation [Pubmed|16166527][protein|search|Spx]: transcription repression [Pubmed|12642660][protein|search|Abh]: transcription repression[Pubmed|20817675]Additional information
A [protein|search|ncRNA] is predicted between '[protein|search|hxlR]' and '[protein|search|srfAA]' [PubMed|20525796]expressed in all cells in a population [PubMed|25448819]the mRNA is cleaved by [rnc|search|RNase III] [PubMed|26883633]References
Reviews
Original publications
8288534,8387999,1938922,16166527,17227471,8825779,8830686,18763711,17218307,17190806,1715856,19605685,19826092,12642660,20148996,16091051,20797616,20525796,21821766,23012477,22511326,20817675,15066026,24425772,25448819,25666134,26582911,26953743,26883633 
