cmoJ [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

alkylmonooxygenase, required for the conversion of S-methyl-cysteine to cysteine

locus: BSU29310

pI: 5.72

mw: 49.00 kDa

function: utilization of S-methyl-cysteine

product: alkylmonooxygenase

essential: no

synonyms: ytnJ

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism] → [category|SW 2.6.4.1|Conversion of S-methyl cysteine to cysteine]

[SW|Categories] containing this gene/protein

• [SW|sulfur metabolism]

This gene is a member of the following [SW|regulons]

• [SW|CymR regulon], [SW|AscR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,001,724 -> 3,003,052

Phenotypes of a mutant

• no growth with S-methyl cysteine [Pubmed|23944997]

The protein

Catalyzed reaction/ biological activity

• oxidation of S-methyl-cysteine [Pubmed|23944997]

Protein family

• ntaA/snaA/soxA(dszA) monooxygenase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|YxeK]

Structure

• [PDB|1YW1] (complex with FMN), [PDB|1TVL]

Expression and Regulation

Operon

• ''[protein|search|snaA]-[protein|search|tcyJ]-[protein|search|tcyK]-[protein|search|tcyL]-[protein|search|tcyM]-[protein|search|tcyN]-[protein|search|cmoO]-[protein|search|cmoI]-[protein|search|cmoJ]-[protein|search|ribR]-[protein|search|sndA]-[protein|search|ytnM]'' [Pubmed|15668000]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|15272571]

Regulation

• repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16109943]
• induced in the presence of S-methyl-cysteine ([protein|search|AscR]) [Pubmed|23944997]

Regulatory mechanism

• [protein|search|CymR]: transcription repression [Pubmed|16109943]
• [protein|search|AscR]: transcription activation [Pubmed|16109943]

References

• 16109943,15668000,15272571,23944997