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folC [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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folC [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

folyl-polyglutamate synthetase
Locus
BSU28080
Isoelectric point
5.81
Molecular weight
48.00 kDa
Function
biosynthesis of folate
Product
folyl-polyglutamate synthetase
Essential
no
E.C.
6.3.2.17
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of folate
  • Groups of genes → Essential genes

    • Categories containing this gene/protein

  • biosynthesis of cofactors, membrane proteins

    • This gene is a member of the following regulons

  • T-box

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1) (according to Swiss-Prot)

    • Protein family

  • folylpolyglutamate synthase family (according to Swiss-Prot)

    • Structure

  • 1FGS (from Lactobacillus casei, 32% identity, 51% similarity) PubMed

    • Localization

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • valS-folC PubMed

    • Sigma factor

  • SigA PubMed

    • Regulation

  • induced by valine limitation (T-box) PubMed

    • Regulatory mechanism

  • T-box: riboswitch, transcription termination/antitermination PubMed

    • References

    Reviews

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    Original Publications

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