folC [Mon Aug 31 2015 13:56:03 GMT+0200 (CEST)]

folyl-polyglutamate synthetase

locus: BSU28080

pI: 5.00

mw: 48.00 kDa

function: biosynthesis of folate

product: folyl-polyglutamate synthetase

essential: no

ec: 6.3.2.17

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|T-box]

Gene

Coordinates on the chromosome (coding sequence): 2,865,312 -> 2,866,604

The protein

Catalyzed reaction/ biological activity

• ATP tetrahydropteroyl-(gamma-Glu)(n) L-glutamate = ADP phosphate tetrahydropteroyl-(gamma-Glu)(n1) (according to Swiss-Prot)

Protein family

• folylpolyglutamate synthase family (according to Swiss-Prot)

Structure

• [PDB|1FGS] (from ''Lactobacillus casei'', 32% identity, 51% similarity) [Pubmed|9618466]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|valS]-[protein|search|folC]'' [Pubmed|9098041]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9098041]

Regulation

• induced by valine limitation ([protein|search|T-box]) [Pubmed|9098041]

Regulatory mechanism

• [protein|search|T-box]: [SW|riboswitch], transcription termination/antitermination [Pubmed|9098041]

References

Reviews

• 19258532

Original Publications

• 9098041