czcD [2019-01-02 15:55:00]

cation diffusion facilitator

locus: BSU26650

pI: 5.86

mw: 34.01 kDa

protein length: 311 aa

gene length: 933 bp

function: cation efflux, resistence against Zn, Cu, Co, Ni

product: cation diffusion facilitator

essential: no

synonyms: yrdO

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.3|Zinc]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.11|Resistance against toxic metals]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 2,723,892 → 2,724,827

The protein

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|7FB5BCC16D688465A820F436F657C49625257884|czcD]-[gene|6D6C324675631B5CAB165D6DF72AA45BF3DB6F29|czcO]
  description: [Pubmed|15948947]

  regulatory mechanism

  • [protein|6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|CzrA]: repression, [Pubmed|15948947], in [regulon|6FB1865734C4DE7BE19D3D1A7E0C687B6D7094E1|CzrA regulon]

  regulation

  • induced in the presence of toxic metal ions (Zn(II), Cd(II), Co(II), Ni(II) and Cu(II)) ([protein|search|CzrA]) [Pubmed|15948947]

Biological materials

Mutant

• BKE26650 (Δ[gene|7FB5BCC16D688465A820F436F657C49625257884|czcD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE26650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAAACTCCTCCTTAC, downstream forward: _UP4_TAAATTTTTTATCTAACTTT
• BKK26650 (Δ[gene|7FB5BCC16D688465A820F436F657C49625257884|czcD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK26650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAAACTCCTCCTTAC, downstream forward: _UP4_TAAATTTTTTATCTAACTTT

References

• 15948947