argD [Mon Aug 31 2015 13:53:36 GMT+0200 (CEST)]

acetylornithine transaminase

locus: BSU11220

pI: 5.93

mw: 40.00 kDa

function: biosynthesis of arginine

product: acetylornithine transaminase

essential: no

ec: 2.6.1.11

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|AhrC regulon], [SW|CodY regulon]

The protein

Catalyzed reaction/ biological activity

• N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate (according to Swiss-Prot)

Protein family

• ArgD subfamily (according to Swiss-Prot)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|argC]-[protein|search|argJ]-[protein|search|argB]-[protein|search|argD]-[protein|search|carA]-[protein|search|carB]-[protein|search|argF]'' [Pubmed|7511775]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|7511775]

Regulation

• repressed by casamino acids ([protein|search|CodY]) [Pubmed|12107147]
• repressed by arginine ([protein|search|AhrC]) [Pubmed|1312212]

Regulatory mechanism

• [protein|search|AhrC]: transcription repression [Pubmed|1312212]
• [protein|search|CodY]: transcription repression [Pubmed|24843172]

References

• 6096675,24843172,12107147