mscL [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

large conductance mechanosensitive channel protein, prevents selective release of cytoplasmic proteins in a hypotonic environment

locus: BSU36360

pI: 4.65

mw: 14.00 kDa

function: resistance to osmotic downshockglycine betaine export

product: large conductance mechanosensitive channel protein

essential: no

synonyms: ywpC

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.7|Coping with hypo-osmotic stress]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|coping with hypo-osmotic stress], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence): 3,743,267 -> 3,743,659

Phenotypes of a mutant

• sensitive to osmotic downshock (> 0.5 M) during logarithmic growth [Pubmed|19252899]

The protein

Protein family

• mscL family (according to Swiss-Prot)

Structure

• [PDB|3HZQ] (MscL of ''Staphylococcus aureus'') [Pubmed|19701184]

[SW|Localization]

• cell membrane [Pubmed|19252899]

Expression and Regulation

Operon

• ''mscL'' [Pubmed|9353933]

Regulation

• expressed in logarithmic phase [Pubmed|19252899]

Biological materials

Mutant

• 1A957 ( ''mscL''::''spec''), [Pubmed|18310427], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A957&Search=1A957 BGSC]

Labs working on this gene/protein

• [SW|Jan Maarten van Dijl], Groningen, Netherlands
• [SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

References

Reviews

• 12626684,19727188,20825352,22685280,24258154

Original Publications

• 17665170,18310427,19160392,16897034,19252899,19701184,9632260,19738010,9353933