cdsA [Mon Feb 01 2016 16:18:31 GMT+0100 (CET)]

phosphatidate cytidylyltransferase

locus: BSU16540

pI: 7.00

mw: 30.00 kDa

function: biosynthesis of phospholipids

product: phosphatidate cytidylyltransferase

essential: yes

ec: 2.7.7.41

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of lipids], [SW|essential genes], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence): 1,722,000 -> 1,722,809

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• CTP phosphatidate = diphosphate CDP-diacylglycerol (according to Swiss-Prot)

Protein family

• CDS family (according to Swiss-Prot)

Structure

• [PDB|4Q2G] (from ''Thermotoga maritima'', 36% identity)

[SW|Localization]

• cell membrane at the septum [Pubmed|15743965,19820159]

Expression and Regulation

Additional information

• the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]

References

• 12884008,15743965,19820159