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carB [Mon May 16 2016 17:03:33 GMT+0200 (CEST)]
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carB [Mon May 16 2016 17:03:33 GMT+0200 (CEST)]

carbamoyl-phosphate transferase-arginine subunit B)
locus
BSU11240
pI
4.00
mw
112.00 kDa
function
biosynthesis of arginine
product
carbamoyl-phosphate transferase-arginine subunit B)
essential
no
ec
6.3.5.5
synonyms
cpa
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|most abundant proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|AhrC regulon], [SW|CodY regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,200,381 -> 1,203,473

    The protein

    Catalyzed reaction/ biological activity

  • 2 ATP L-glutamine HCO3- H2O = 2 ADP phosphate L-glutamate carbamoyl phosphate (according to Swiss-Prot)

    • Protein family

  • carB family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [SW|PyrAB]

    • Structure

  • [PDB|1JDB] (from ''Escherichia coli'', 47% identity, 64% similarity) [Pubmed|10089390]

    • [SW|Interactions]

  • [protein|search|CarA]-[protein|search|CarB]

    • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids= 17981983 PubMed]

    • Expression and Regulation

    Operon

  • ''[protein|search|argC]-[protein|search|argJ]-[protein|search|argB]-[protein|search|argD]-[protein|search|carA]-[protein|search|carB]-[protein|search|argF]'' [Pubmed|7511775]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|7511775]

    • Regulation

  • repressed by casamino acids ([protein|search|CodY]) [Pubmed|12107147]
  • repressed by arginine ([protein|search|AhrC]) [Pubmed|1312212]

    • Regulatory mechanism

  • [protein|search|AhrC]: transcription repression [Pubmed|1312212]
  • [protein|search|CodY]: transcription repression [Pubmed|24843172]

    • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids= 17981983 PubMed]
  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

    • References

  • 6096675,12107147,15378759,24843172