bpsA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

type III polyketide synthase

locus: BSU22050

pI: 7.96

mw: 40.00 kDa

function: polyketide synthesis

product: type III polyketide synthase

essential: no

ec: 2.3.1.74

synonyms: bcsA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]

[SW|Categories] containing this gene/protein

• [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds], [SW|membrane proteins], [SW|sporulation proteins]

Gene

Coordinates on the chromosome (coding sequence): 2,316,956 -> 2,318,053

The protein

Catalyzed reaction/ biological activity

• synthesis of triketide pyrones from long-chain fatty acyl CoA thioesters as starter substrates and malonyl-CoA as an extender substrate [Pubmed|19465653]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|bpsA]-[protein|search|bpsB]'' [Pubmed|19465653]

Biological materials

Mutant

• BKE22050 (''[protein|search|bpsA]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab)
• GP1820 (''[protein|search|bpsA]''::''erm'', available in [SW|Jörg Stülke]'s lab)

References

• 19465653