nagP [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

N-acetylglucosamine-specific phosphotransferase system, EIICB of the PTS

Locus: BSU07700

Isoelectric point: 7.13

Molecular weight: 48.00 kDa

Function: N-acetylglucosamine uptake and phosphorylation

Product: N-acetylglucosamine-specific PTS, EIICB

Essential: no

E.C.: 2.7.1.69

Synonyms: yflF

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → Phosphotransferase system → Sugar specific PTS proteins
• Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of amino sugars
• Metabolism → Amino acid/ nitrogen metabolism → Utilization of nitrogen sources other than amino acids → Utilization of amino sugars
• Groups of genes → Membrane proteins
• Groups of genes → Phosphoproteins → Phosphorylation on a Cys residue

Categories containing this gene/protein

• phosphotransferase systems, utilization of specific carbon sources, membrane proteins, phosphoproteins

This gene is a member of the following regulons

• NagR regulon

Gene

Coordinates on the chromosome (coding sequence): 840,656 -> 842,014

Phenotypes of a mutant

• no growth on N-acetylglucosamine PubMed

The protein

Catalyzed reaction/ biological activity

• Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate (according to Swiss-Prot)

Protein family

• PTS permease, glucose permease (Glc) family PubMed

Paralogous protein(s)

• GamP

Localization

• cell membrane (according to Swiss-Prot), membrane associated PubMed

Expression and Regulation

Operon

• nagP PubMed

Sigma factor

• SigA PubMed

Regulation

• induced in the presence of N-acetylglucosamine (NagR) PubMed

Regulatory mechanism

• NagR: transcription repression PubMed

References

Reviews

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Original publications

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