pbuX [2017-05-15 18:53:56]

xanthine transport in/out via proton symport

locus: BSU22060

pI: 8.79

mw: 46.08 kDa

protein length: 438 aa

gene length: 1314 bp

function: xanthine uptake

product: xanthine permease

essential: no

synonyms: ypaQ

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.6|Nucleotide/ nucleoside transporter]
• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 2,318,127 → 2,319,443

The protein

Paralogous protein(s)

• [protein|53950BFDC128DE46F3F43BDB9D0FDB3D645152DF|PucJ], [protein|3162EF36F4441A1E4EBBFDAD19F6768D8EF21B29|PucK]

Structure

• [PDB|5I6C] (27% identity)

[SW|Localization]

• membrane [Pubmed|18763711]

Expression and Regulation

Operons

• genes: [gene|02C84C9A8C0008CC253CBF13584A4B5B2D2B510C|xpt]-[gene|7D56F85FBD3AAC66607DD7465592EEAE09D61C98|pbuX]
  description: [Pubmed|9098051]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9098051], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [regulon|G-box|G-box]: termination, [SW|riboswitch] [Pubmed|9098051,12787499], in [regulon|G-box|G-box]
  • [protein|A8C82F5825DE0921DA6B4ACDE0CC31EC7749273C|PurR]: repression, (molecular inducer: PRPP) [Pubmed|11591660], in [regulon|A8C82F5825DE0921DA6B4ACDE0CC31EC7749273C|PurR regulon]

  regulation

  • induced in the absence of guanine ([SW|G-box]) [Pubmed|12787499]

References

• 12923093,11591660,9098051,11591660,18763711