pbuX [Mon Aug 31 2015 13:55:12 GMT+0200 (CEST)]

xanthine transport in/out via proton symport

locus: BSU22060

pI: 8.79

mw: 46.00 kDa

function: xanthine uptake

product: xanthine permease

essential: no

synonyms: ypaQ

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.6|Nucleotide/ nucleoside transporter]
• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

syns: ypaQ

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|G-box], [SW|PurR regulon]

The protein

[SW|Localization]

• membrane [Pubmed|18763711]

Expression and Regulation

Operon

• ''[protein|search|xpt]-[protein|search|pbuX]'' [Pubmed|9098051]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|9098051]

Regulation

• repressed in the presence of adenine or adenosine ([protein|search|PurR]) [Pubmed|11591660]
• induced in the absence of guanine ([protein|search|G-box]) [Pubmed|12787499]

Regulatory mechanism

• [protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [Pubmed|9098051,12787499]
• [protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|11591660]

References

• 12923093,11591660,9098051,11591660,18763711