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spoIIE [2017-03-30 15:17:27]
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spoIIE [2017-03-30 15:17:27]

protein serine phosphatase, septum-associated PP2C, dephosphorylation of SpoIIAA
Locus
BSU00640
Isoelectric point
6.00
Molecular weight
91.00 kDa
Protein length
827 aa Sequence Blast
Gene length
2481 bp Sequence Blast
Function
control of SigF activity
required for normal formation of the asymmetric septum
Product
protein serine phosphatase, septum-associated PP2C
Essential
no
E.C.
3.1.3.16
Synonyms
spoIIH, spoIIK
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Protein synthesis, modification and degradation → Protein modification → Protein phosphatases
  • Information processing → Regulation of gene expression → Sigma factors and their control → Control of sigma factors
  • Groups of genes → Membrane proteins

    • This gene is a member of the following regulons

  • Spo0A regulon

    • Gene

    Coordinates
    70,538 -> 73,021

    The protein

    Catalyzed reaction/ biological activity

  • dephosphorylation of SpoIIAA

    • Protein family

  • PP2C phosphatase

    • Effectors of protein activity

  • degraded by FtsH, oligomerization and polar localization protect SpoIIE from degradation PubMed

    • Structure

  • 3T91 (phosphatase domain) PubMed

    • Localization

  • cell membrane (according to Swiss-Prot)
  • localizes to the polar cell division sites where it causes FtsZ to relocate from mid-cell to form polar Z-rings
  • forespore PubMed
  • localizes to the cell poles (via DivIVA) PubMed
  • proper localization and stability depend on SpoIIQ PubMed

    • Expression and Regulation

    Operons

    Genes
    spoIIE
    Description
    (DBTBS) null

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • Spo0A: activation, PubMed, in Spo0A regulon

    • Regulation

  • expressed under conditions that trigger sporulation (Spo0A) PubMed
    • view in new tab

    Genes
    spoIIE-yabS-yabT-tilS-hprT-ftsH
    Description
    PubMed

    Sigma factors

  • SigF: sigma factor, PubMed, in SigF regulon

    • Regulation

  • expressed early during sporulation in the forespore (SigF) PubMed
    • view in new tab

    Biological materials

    Mutant

  • MGNA-A083 (spoIIE::erm), available at the NBRP B. subtilis, Japan

    • Labs working on this gene/protein

  • Imrich Barak, Slovak Academy of Science, Bratislava, Slovakia homepage

    • References

    Modeling of SigF activation

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    Original Publications

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