phosphoribosylglycinamide formyltransferase, irreversible
function
purine biosynthesis
product
phosphoribosylglycinamide formyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides]This gene is a member of the following [SW|regulons]
[SW|G-box], [SW|PurR regulon]The protein
Catalyzed reaction/ biological activity
10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide (according to Swiss-Prot)Protein family
GART family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YkkE]Structure
[PDB|3P9X] (from ''B. halodurans'', 51% identity, 70% similarity)Expression and Regulation
Operon
''[protein|search|purE]-[protein|search|purK]-[protein|search|purB]-[protein|search|purC]-[protein|search|purS]-[protein|search|purQ]-[protein|search|purL]-[protein|search|purF]-[protein|search|purM]-[protein|search|purN]-[protein|search|purH]-[protein|search|purD]'' [Pubmed|3036807][SW|Sigma factor]
[protein|search|SigA] [Pubmed|3036807]Regulation
repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]repressed in the presence of guanine([protein|search|G-box]) [Pubmed|3036807]Regulatory mechanism
[protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|7638212,2536750][protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [http://www.ncbi.nlm.nih.gov/sites/entrez/3036807 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/12787499 PubMed2]References
8121396,3036807,12923093,19574646,7638212 
