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ftsL [2018-06-04 12:30:42]
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ftsL [2018-06-04 12:30:42]

[SW|cell division] protein (septum formation), controls together with [protein|B317D7E51824DD70EF84E4D5D7290D601BF4FAB6|EzrA] dynamics of the [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|FtsZ] ring
locus
BSU15150
pI
10.08
mw
12.93 kDa
protein length
117 aa Sequence Blast
gene length
351 bp Sequence Blast
function
septum formation
product
[SW|cell division] protein
essential
yes
synonyms
ylxB,yllD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    1,581,597 → 1,581,950

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Protein family

  • ftsL family (according to Swiss-Prot)

    • Effectors of protein activity

  • degraded by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|RasP], stabilized against [protein|CB50289535EA537F63BADD459BD11AA7759A6658|RasP] cleavage by [protein|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|DivIC] [Pubmed|20644139]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • localizes to the division site, this depends on [protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|FtsW] [Pubmed|27895631]

    • Expression and Regulation

    Operons

    genes
    [gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|mraW]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB]
    description
    [Pubmed|8636036,8244929]

    regulation

  • constitutively expressed [Pubmed|15758244]
    • view in new tab

    additional information

  • FtsL is degraded by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|RasP] [PubMed|17020588]

    • Biological materials

    Mutant

  • MGNA-B127 (ftsL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1126 NBRP B. subtilis, Japan]

    • FLAG-tag construct

  • GP2004 ''ftsL-3xFLAG ermC'' (based on [SW|pGP1087]), available in [SW|Jörg Stülke]'s lab

    • References

    Reviews

  • 20836086

    • Original Publications

  • 9720875,10792716,16936019,16549676,17020588,8636036,10986263,11994149,10844672,19429628,20644139,21219466,23701187,20870765,286740701