ftsL

[SW|cell division] protein (septum formation), controls together with [protein|B317D7E51824DD70EF84E4D5D7290D601BF4FAB6|EzrA] dynamics of the [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|FtsZ] ring

locus: BSU_15150

pI: 10.08

mw: 12.93 kDa

protein length: 117 aa

gene length: 354 bp

function: septum formation

product: [SW|cell division] protein, member of the [SW|divisome]

essential: yes

synonyms: ylxB,yllD

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 1,581,597 1,581,950

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Protein family

• FtsL family (single member, according to UniProt)

Effectors of protein activity

• degraded by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|RasP], stabilized against [protein|CB50289535EA537F63BADD459BD11AA7759A6658|RasP] cleavage by [protein|FE0E60B875E72AEF5174A89C7AE5556FF59B19D5|DivIC] [Pubmed|20644139]

[SW|Localization]

• cell membrane (according to UniProt)
• localizes to the division site, this depends on [protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|FtsW] [Pubmed|27895631]

Expression and Regulation

Operons

• genes: [gene|A7131ACFA0CF5C222237C76E502D4AAD1F9BA3E4|mraZ]-[gene|1F894D6895CE13AA006CFE13A702E46C568F6E79|mraW]-[gene|79712F4CF884A660C71B45B3397AEFA5C0AFA683|ftsL]-[gene|EBEFF9E0A524DCDA19382E5401B923B805E4C559|pbpB]
  description: [Pubmed|8636036,8244929]

  regulation

  • constitutively expressed [Pubmed|15758244]

additional information

• FtsL is degraded by [protein|CB50289535EA537F63BADD459BD11AA7759A6658|RasP] [PubMed|17020588]

Biological materials

Mutant

• MGNA-B127 (ftsL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1126 NBRP B. subtilis, Japan]

FLAG-tag construct

• GP2004 ''ftsL-3xFLAG ermC'' (based on [SW|pGP1087]), available in [SW|Jörg Stülke]'s lab

References

Reviews

• 20836086

Original Publications

• 9720875,10792716,16936019,16549676,17020588,8636036,10986263,11994149,10844672,19429628,20644139,21219466,23701187,20870765,286740701,29443967,33077634