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rpsD
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rpsD

ribosomal protein
locus
BSU_29660
pI
10.24
mw
22.69 kDa
protein length
200 aa Sequence Blast
gene length
603 bp Sequence Blast
function
translation
product
ribosomal protein S4 (BS4)
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]

    • Gene

    Coordinates
    3,035,730 3,036,332

    Phenotypes of a mutant

  • essential [Pubmed|23002217,12682299]

    • The protein

    Protein family

  • [SW|S4 RNA-binding domain] superfamily (according to http://www.ebi.ac.uk/interpro/entry/IPR036986 Interpro)
  • universal [SW|ribosomal protein] uS4 family (single member, according to UniProt)

    • [SW|Domains]

  • [SW|S4 RNA-binding domain] (aa 92-155) (according to UniProt)

    • Structure

  • [PDB|1C06] (Geobacillus stearothermophilus)
  • [PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]

    • Expression and Regulation

    Operons

    genes
    [gene|789D08564463542B8D96FC12F408549A669703CE|rpsD]
    description
    [Pubmed|1699930]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1699930], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]
  • [protein|789D08564463542B8D96FC12F408549A669703CE|RpsD]: autorepression, [pubmed|27120414,23611891,1906866], in [regulon|789D08564463542B8D96FC12F408549A669703CE|RpsD regulon]

    • regulation

  • autorepression of ''rpsD'' expression upon binding of excess [protein|789D08564463542B8D96FC12F408549A669703CE|RpsD] to a [SW|RNA switch] in the untranslated region of the ''rpsD'' mRNA [Pubmed|27120414,23611891,1906866]

    • additional information

  • term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''rpsD'' [Pubmed|27120414]
  • the [SW|RNA switch] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
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    References

  • 1699930,2121712,6420647,1400226,1906866,19653700,11489846,23611891,23002217,25548247,25548248,26115952,25903689,27120414,29794222