comEA [Mon Aug 31 2015 13:55:41 GMT+0200 (CEST)]

membrane DNA receptor, plays an important role in the transfer of transforming DNA into the DNA channel and in controlling the rate of DNA uptake

Locus: BSU25590

Isoelectric point: 4.82

Molecular weight: 21.00 kDa

Function: genetic competence

Product: membrane DNA receptor

Essential: no

Synonyms: comD

Genomic Context

Loading

Categories containing this gene/protein

• Information processing → Genetics → Genetic competence
• Lifestyles → Exponential and early post-exponential lifestyles → Genetic competence
• Groups of genes → Membrane proteins

Syns: comD

Categories containing this gene/protein

• genetic competence, membrane proteins

This gene is a member of the following regulons

• ComK regulon, ComN regulon

Gene

Phenotypes of a mutant

• strongly reduced transformation rate PubMed

The protein

Domains

• extracellular DNA-binding domain

Structure

• 2DUY (from Thermus thermophilus hb8, 37% identity, 60% similarity)

Localization

• cell membrane, no distinct position PubMed
• integral membrane protein PubMed

Interactions

• ComEC-ComEA PubMed

Expression and Regulation

Operon

• comEA-comEB-comEC PubMed

Sigma factor

• SigA PubMed

Regulatory mechanism

• post-translational control by ComN PubMed
• yutB is required for transcription PubMed
• ComK: transcription activation PubMed

References

Reviews

Loading

Original publications

Loading