comEA [Mon Aug 31 2015 13:55:41 GMT+0200 (CEST)]

membrane DNA receptor, plays an important role in the transfer of transforming DNA into the DNA channel and in controlling the rate of DNA uptake

locus: BSU25590

pI: 4.82

mw: 21.00 kDa

function: genetic competence

product: membrane DNA receptor

essential: no

synonyms: comD

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

syns: comD

[SW|Categories] containing this gene/protein

• [SW|genetic competence], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|ComK regulon], [SW|ComN regulon]

Gene

Phenotypes of a mutant

• strongly reduced transformation rate [Pubmed|22398145]

The protein

[SW|Domains]

• extracellular DNA-binding domain

Structure

• [PDB|2DUY] (from ''Thermus thermophilus hb8'', 37% identity, 60% similarity)

[SW|Localization]

• cell membrane, no distinct position [Pubmed|21278288]
• integral membrane protein [Pubmed|24164455]

[SW|Interactions]

• [SW|ComEC]-[SW|ComEA] [Pubmed|17630974]

Expression and Regulation

Operon

• ''[SW|comEA]-[SW|comEB]-[SW|comEC]'' [Pubmed|7968523,19028902]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|7968523]

Regulatory mechanism

• post-translational control by [protein|search|ComN] [Pubmed|19028902]
• ''[protein|search|yutB]'' is required for transcription [Pubmed|19028902]
• [protein|search|ComK]: transcription activation [Pubmed|8196543]

References

Reviews

• 15083159

Original publications

• 9987128,11814663,7768800,16751195,7968523,17630974,21278288,19028902,21707789,22398145,24164455