comA [Thu Mar 03 2016 10:14:41 GMT+0100 (CET)]

two-component system response regulator, controls gene expression in response to cell density (concentration of ComX)

Locus: BSU31680

Isoelectric point: 4.00

Molecular weight: 23.00 kDa

Function: regulation of genetic competence and quorum sensing

Product: two-component system response regulator

Essential: no

E.C.: 4.4.1.19

Synonyms: srfB, comAA

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → Genetic competence
• Information processing → Regulation of gene expression → Transcription factors and their control → Two-component system response regulators
• Information processing → Regulation of gene expression → Quorum sensing
• Lifestyles → Exponential and early post-exponential lifestyles → Genetic competence
• Groups of genes → Phosphoproteins → Phosphorylation on an Asp residue

Categories containing this gene/protein

• genetic competence, transcription factors and their control, quorum sensing, phosphoproteins

Gene

Coordinates on the chromosome (coding sequence): 3,252,804 -> 3,253,448

The protein

Protein family

• ComA family (according to Swiss-Prot)

Modification

• phosphorylated by ComP on an Asp residue

Effectors of protein activity

• phosphorylation activates DNA binding
• DNA-binding activity of ComA is inhibited by RapC PubMed, RapD PubMed, RapF PubMed, RapH PubMed and RapK PubMed

Structure

• 1U83
• 3ULQ (structure of the complex between the DNA-binding C-terminal domain of ComA with RapF) PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Interactions

• RapC-ComA PubMed
• RapF-ComA PubMed
• RapH-ComA PubMed
• ComP-ComA
• ComA-RpoA PubMed
• ComA-SigA PubMed

Expression and Regulation

Operon

• comA-yuxO PubMed

Sigma factor

• SigA PubMed

References

Reviews

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Original Publications

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