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comA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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comA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

two-component system response regulator, controls gene expression in response to cell density (concentration of ComX)
locus
BSU31680
pI
4.00
mw
23.00 kDa
function
regulation of genetic competence and quorum sensing
product
two-component system response regulator
essential
no
ec
4.4.1.19
synonyms
srfB, comAA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

    • [SW|Categories] containing this gene/protein

  • [SW|genetic competence], [SW|transcription factors and their control], [SW|quorum sensing], [SW|phosphoproteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,252,804 -> 3,253,448

    The protein

    Protein family

  • ComA family (according to Swiss-Prot)

    • Modification

  • phosphorylated by [protein|search|ComP] on an Asp residue

    • Effectors of protein activity

  • phosphorylation activates DNA binding
  • DNA-binding activity of ComA is inhibited by [protein|search|RapC] [Pubmed|12950917], [protein|search|RapD] [Pubmed|17227471], [protein|search|RapF] [Pubmed|15968044,22215984], [protein|search|RapH] [Pubmed|17581123] and [protein|search|RapK] [Pubmed|16816200]

    • Structure

  • [PDB|1U83]
  • [PDB|3ULQ] (structure of the complex between the DNA-binding C-terminal domain of [protein|search|ComA] with [protein|search|RapF]) [Pubmed|22215984]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • [SW|Interactions]

  • [protein|search|RapC]-[protein|search|ComA] [Pubmed|12950917]
  • [protein|search|RapF]-[protein|search|ComA] [Pubmed|15968044,22215984]
  • [protein|search|RapH]-[protein|search|ComA] [Pubmed|17581123]
  • [protein|search|ComP]-[protein|search|ComA]
  • [SW|ComA]-[SW|RpoA] [Pubmed|26582911]
  • [SW|ComA]-[SW|SigA] [Pubmed|26582911]

    • Expression and Regulation

    Operon

  • ''[protein|search|comA]-[protein|search|yuxO]'' [Pubmed|2507523]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|2507523]

    • References

    Reviews

  • 20030732,12576575

    • Original Publications

  • 17227471,11133937,2116363,12067344,8387999,19202088,10094672,8643670,11267663,15968044,16816200,10447896,12950917,20302877,12270822,17581123,16816200,2507523,20208433,22215984,24130811,24425772,24788106,25598361,25757097,26582911,26787913