ABC transporter (permease), export of the spore killing factor
function
export of the spore killing factor SkfA
product
ABC transporter (permease)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.3|Export of peptides][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins][category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.4|Prophage 1][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|toxins, antitoxins and immunity against toxins], [SW|membrane proteins], [SW|prophage 1]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|PhoP regulon], [SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
217,697 -> 219,040
Phenotypes of a mutant
inactivation of ''[SW|skfF]'' reduces sporulation efficiency to 62.3% that of wild type cells [Pubmed|26735940]The protein
[SW|Localization]
membrane (according to Swiss-Prot)[SW|Interactions]
[protein|search|SkfE]-[protein|search|SkfF] [Pubmed|11731129]Expression and Regulation
Operon
''[protein|search|skfA]-[protein|search|skfB]-[protein|search|skfC]-[protein|search|skfE]-[protein|search|skfF]-[protein|search|skfG]-[protein|search|skfH]'' [Pubmed|16816204][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16452424]Regulation
expressed under conditions that trigger sporulation ([SW|Spo0A]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647,15687200 PubMed]repressed during logrithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]induced by phosphate starvation ([protein|search|PhoP]) [Pubmed|16816204]Regulatory mechanism
[SW|Spo0A]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647,15687200 PubMed][protein|search|AbrB]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed][protein|search|PhoP]: transcription activation [Pubmed|16816204]Additional information
Northern blotting during during phosphate limitation showed an intense 0.25 kb '[protein|search|skfA]'-specific transcript, and a weaker 6.5 kb '[protein|search|skfA]-[protein|search|skfB]-[protein|search|skfC]-[protein|search|skfE]-[protein|search|skfF]-[protein|search|skfG]-[protein|search|skfH]' transcript. [http://www.ncbi.nlm.nih.gov/pubmed/16816204 PubMed]References
Reviews
Original Publications
10092453,12817086,16816204,14651647,15687200,15687200,17720793,11731129,17449691,18840696,26735940 
