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folE [Wed Feb 15 2017 18:07:28 GMT+0100 (CET)]
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folE [Wed Feb 15 2017 18:07:28 GMT+0100 (CET)]

GTP cyclohydrolase I
Locus
BSU22780
Isoelectric point
6.00
Molecular weight
21.00 kDa
Function
biosynthesis of folate
Product
GTP cyclohydrolase IA
Essential
yes
E.C.
3.5.4.16
Synonyms
mtrA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of folate
  • Information processing → Protein synthesis, modification and degradation → Translation → tRNA modification and maturation
  • Groups of genes → Essential genes

    • Categories containing this gene/protein

  • biosynthesis of cofactors

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,384,783 -> 2,385,355

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • GTP H2O = formate 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

    • Protein family

  • citrate synthase family (according to Swiss-Prot)

    • Cofactors

  • zinc-dependent enzyme PubMed

    • Structure

  • 3D2O (enzyme from Neisseria gonorrhoeae) PubMed

    • Expression and Regulation

    Operon

  • folE-mtrB PubMed

    • Sigma factor

  • SigA PubMed

    • Regulation

  • constitutive PubMed

    • References

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