folE [Wed Feb 15 2017 18:07:28 GMT+0100 (CET)]

GTP cyclohydrolase I

locus: BSU22780

pI: 6.00

mw: 21.00 kDa

function: biosynthesis of folate

product: GTP cyclohydrolase IA

essential: yes

ec: 3.5.4.16

synonyms: mtrA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

Gene

Coordinates on the chromosome (coding sequence): 2,384,783 -> 2,385,355

Phenotypes of a mutant

• essential [Pubmed|28189581]

The protein

Catalyzed reaction/ biological activity

• GTP H₂O = formate 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

Protein family

• citrate synthase family (according to Swiss-Prot)

[SW|Cofactors]

• zinc-dependent enzyme [Pubmed|19767425]

Structure

• [PDB|3D2O] (enzyme from ''Neisseria gonorrhoeae'') [Pubmed|17032654]

Expression and Regulation

Operon

• ''[protein|search|folE]-[protein|search|mtrB]'' [Pubmed|2123343]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|2123343]

Regulation

• constitutive [Pubmed|19767425]

References

• 1551827,2123343,17032654,19767425,28189581