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folE [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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folE [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

GTP cyclohydrolase I
locus
BSU22780
pI
6.34
mw
21.00 kDa
function
biosynthesis of folate
product
GTP cyclohydrolase IA
essential
no
ec
3.5.4.16
synonyms
mtrA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
    • syns
    mtrA

    [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]

    • The protein

    Catalyzed reaction/ biological activity

  • GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

    • Protein family

  • citrate synthase family (according to Swiss-Prot)

    • [SW|Cofactors]

  • zinc-dependent enzyme [Pubmed|19767425]

    • Structure

  • [PDB|3D2O] (enzyme from ''Neisseria gonorrhoeae'') [Pubmed|17032654]

    • Expression and Regulation

    Operon

  • ''[protein|search|folE]-[protein|search|mtrB]'' [Pubmed|2123343]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|2123343]

    • Regulation

  • constitutive [Pubmed|19767425]

    • References

  • 1551827,2123343,17032654,19767425