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araE [2018-02-09T22:33:18.000Z]
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araE [2018-02-09T22:33:18.000Z]

L-arabinose permease (proton symporter)
locus
BSU33960
pI
9.26
mw
50.25 kDa
protein length
464 aa Sequence Blast
gene length
1392 bp Sequence Blast
function
uptake of arabinose, galactose and xylose
product
L-arabinose permease
essential
no
synonyms
yvbR
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.3|Carbohydrate transporter]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.5|Utilization of xylan/ xylose]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.6|Utilization of arabinan/ arabinose/ arabitol]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,484,072 → 3,485,466

    The protein

    Catalyzed reaction/ biological activity

  • transports arabinose, and also xylose and galactose [Pubmed|9620981]

    • Paralogous protein(s)

  • [protein|0757FAEB38AA1C599C5067794AF83A4BA5912DC9|CsbC], [protein|4A77316AA94F9C11DB70AB76711AACBD28098AA1|IolT], [protein|8B0701B5694ABA8142476CB896E590FE1981D7DB|YfiG], [protein|A84AC4E40E7C722E27AE9C24ACECFEABD51B57BE|YncC], [protein|7CE5A42042E5D52768735E795DB805530691D8A6|YwtG]

    • Structure

  • [PDB|4JA4] (the xylose transporter XylE from ''E. coli'', 39% identity, 68% similarity) [Pubmed|23624861]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|770D9A5BEEEABE9C3FC772E74001329206ECFAB3|araE]
    description
    [Pubmed|9401028]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9401028], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|12949161], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]
  • [protein|A567466894AE9DE7CDE7816615433A37532297B5|AraR]: repression, [Pubmed|9401028,9620981,10417639], in [regulon|A567466894AE9DE7CDE7816615433A37532297B5|AraR regulon]

    • regulation

  • induced by arabinose ([protein|search|AraR]) [Pubmed|9401028,9620981,10417639]
    • view in new tab

    Biological materials

    Mutant

  • BKE33960 (Δ[gene|770D9A5BEEEABE9C3FC772E74001329206ECFAB3|araE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33960 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCCTGCCCTCCCGAA, downstream forward: _UP4_TGAAAACGCTTTAATGAAAC
  • BKK33960 (Δ[gene|770D9A5BEEEABE9C3FC772E74001329206ECFAB3|araE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33960 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCCCTGCCCTCCCGAA, downstream forward: _UP4_TGAAAACGCTTTAATGAAAC

    • References

  • 9401028,9620981,23624861,10417639,9620981,12949161