membrane-anchored protein quality control protease, serine protease Do
function
protein quality control
product
serine protease Do
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.1|Protein quality control][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|proteolysis], [SW|heat shock proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CssR regulon]The protein
Catalyzed reaction/ biological activity
required for folding of the secreted protein [protein|search|YqxI] [Pubmed|23937099]Protein family
PDZ (DHR) domain (according to Swiss-Prot)Paralogous protein(s)
[protein|search|HtrC][SW|Localization]
cell membrane (according to Swiss-Prot)extracellular (signal peptide) [Pubmed|18957862]randomly distributed in foci throughout the cell surface [Pubmed|22307758]Expression and Regulation
Operon
''htrA'' (according to [http://dbtbs.hgc.jp/COG/prom/htrA.html DBTBS])[SW|Sigma factor]
[protein|search|SigA] [Pubmed|10692364]Regulation
expressed under conditions of secretion stress ([protein|search|CssR]) [Pubmed|11555295]induced by rhamnolipids [Pubmed|22092710]Regulatory mechanism
[protein|search|CssR]: transcription activation [Pubmed|11555295]Biological materials
Mutant
1A933 (no resistance), [Pubmed|10692364], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A933&Search=1A933 BGSC]References
Reviews
22688815,21326199,25212246 Original publications
17600057,12270824,11555295,18957862,10692364,21624103,22307758,22092710,24362423,23937099,24115457,11133960 
