branched-chain amino acid transporter
function
uptake of branched-chain amino acids
product
branched-chain amino acid transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.5|BCAA transporters][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.12|Biosynthesis/ acquisition of branched-chain amino acids][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|ScoC regulon]Gene
Phenotypes of a mutant
no phenotype for the single mutant, the triple ''[protein|search|bcaP] [protein|search|brnQ] [protein|search|braB]'' mutant is strongly impaired in the transport of isoleucine and valine at low concentrations [Pubmed|25645558]The protein
Catalyzed reaction/ biological activity
high affinity uptake of isoleucine and valine [Pubmed|25645558]Protein family
branched chain amino acid transporter family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|BrnQ][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|braB]'' [Pubmed|9387221][SW|Sigma factor]
[SW|SigA] [Pubmed|26473603]Regulation
induced in the absence of branched-chain amino acids ([SW|CodY], [SW|ScoC]) [Pubmed|26473603]Regulatory mechanism
[SW|CodY]: transcription repression [Pubmed|26473603][SW|ScoC]: transcription repression [Pubmed|26473603]Additional information
note that [SW|CodY] represses the expression of "[SW|scoC]", therefore ''[protein|search|braB]'' expression is increased at intermediate levels of [SW|CodY] activity [Pubmed|26473603]References
9387221,25645558,26473603 
