[SW|MarR family|MarR/DUF24 family] transcription repressor of [gene|CFFFFE96FB7AEEF7190F81332369F0A6834C34A4|azoR1], [gene|B7A0D1B3CAA2733A33BCCDDB6774ABF1A0223473|catD]-[gene|search|catE ]and [gene|search|yodC ]expression
function
regulation of quinone and diamide detoxification
product
[SW|MarR family|MarR/DUF24 family] transcription repressor
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]Gene
Coordinates
2,127,345 2,127,683
Phenotypes of a mutant
increased resistance to catechol, quinones and diamide [Pubmed|20639328]The protein
Protein family
[SW|MarR family|MarR/DUF24 family]Paralogous protein(s)
[protein|91085DA5E71B88E533D2E1D1BFB53E908116C6AA|HypR], [protein|C57DDC9710CB557179B062F9C5D786DB02A3B5FC|YkvN], [protein|D9A187961CFB9496A6712E9E48AAD384357A3E1C|HxlR], [protein|E757C4B329A99E3D0C70C77437DF4DDA300CA5E7|YdzF], [protein|5B9C4932B2E76D6B8F6BDB640D1ADEE28F488FAD|CatR], [protein|51B1913B59C1876CCED4A88414797B3A22BE4E3C|YdeP], [protein|1E74F0557FF9ECB404B6544831F4E0A162473423|YtcD] Modification
redox-controlled by intersubunit disulfide formation of Cys6 and Cys101' in response to quinones and diamideEffectors of protein activity
responds distinctly to diamide or methyl-p-benzoquinone [Pubmed|27531959]Structure
[PDB|5HS7] (reduced form) [Pubmed|27531959][PDB|5HS8] (diamide-treated form) [Pubmed|27531959][PDB|5HS9] (quinone-bound form) [Pubmed|27531959]additional information
information on binding sites can be found in the [http://www.prodoric2.de/detail.php?acc=MX000216 PRODORIC2 database]Expression and Regulation
Operons
genes
[gene|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]
description
[pubmed|22383849]
regulatory mechanism
[protein|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|YodB]: repression, in [regulon|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|YodB regulon]view in new tabBiological materials
Mutant
MGNA-B433 (yodB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1432 NBRP B. subtilis, Japan]BKE19540 ([gene|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE19540 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGTCTTCATCCCTTCA, downstream forward: _UP4_TAAGGAAAGCGGCACCTGAABKK19540 ([gene|73AFDF65BE89C0E2CC59AF2AF64C29BD99D785DF|yodB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK19540 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAGTCTTCATCCCTTCA, downstream forward: _UP4_TAAGGAAAGCGGCACCTGAAlabs
[SW|Haike Antelmann],University of Greifswald, GermanyReferences
Reviews
Original Publications
17158660,17407181,18208493,20639328,20652907,21749987,27531959