laccase, bilirubin oxidase, spore coat protein (outer)
function
resistance of the spore
product
laccase, bilirubin oxidase
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.5|Class V][category|SW 6|Groups of genes] → [category|SW 6.11|Efp-dependent proteins][SW|Categories] containing this gene/protein
[SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|GerE regulon], [SW|SigK regulon], [SW|Efp-dependent proteins]Gene
Coordinates on the chromosome (coding sequence)
683,462 -> 685,003
The protein
Structure
[PDB|2BHF] (reduced form)[SW|Localization]
outer spore coat, more abundant at the mother cell-distal pole of the forespore, localization depends on [protein|search|CotE] [Pubmed|22171814,19933362]Expression and Regulation
Operon
''cotA'' [Pubmed|22383849][SW|Sigma factor]
[protein|search|SigK] [Pubmed|15699190,3135411]Regulation
expressed late during sporulation in the mother cell ([protein|search|SigK], [protein|search|GerE]) [Pubmed|15383836]Regulatory mechanism
[protein|search|GerE]: transcription repression [Pubmed|15383836]Additional information
[protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]Biological materials
Mutant
1S101 ( ''cotA''::''cat''), [Pubmed|2821284], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S101&Search=1S101 BGSC]1S134 ( ''cotA''::''kan''), [Pubmed|11514528], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S134&Search=1S134 BGSC]References
Reviews
Original publications
15699190,3135411,11514528,1518043,2821284,19933362,20200715,20551082,20822511,21369750,22281748,23859715,22171814,22410485,15383836,26062535,24293734,24733162,25259857,25847445,26784443 
