mhqA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

hydroquinone-specific dioxygenase, confers resistence to methyl-hydroxyquinone

locus: BSU12870

pI: 5.40

mw: 35.00 kDa

function: resistence to methyl-hydroxyquinone

product: hydroquinone-specific dioxygenase

essential: no

synonyms: ykcA

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

[SW|Categories] containing this gene/protein

• [SW|resistance against oxidative and electrophile stress]

This gene is a member of the following [SW|regulons]

• [SW|MhqR regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,353,080 -> 1,354,030

The protein

Protein family

• extradiol ring-cleavage dioxygenase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|MhqE], [protein|search|MhqO]

Structure

• [PDB|3OAJ] ([protein|search|MhqO], 34% identical residues)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''mhqA'' [Pubmed|17725564]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|17725564]

Regulation

• induced by catechol and 2-methylhydroquinone ([protein|search|MhqR]) [Pubmed|17725564]

Regulatory mechanism

• [protein|search|MhqR]: transcription repression [Pubmed|17725564]

References

• 17407181,17725564