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ctaC [2017-11-14 13:37:57]
cytochrome-c oxidase (subunit II)
product
cytochrome-c oxidase (subunit II)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
1,560,466 → 1,561,536
The protein
Catalyzed reaction/ biological activity
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O (according to Swiss-Prot)Protein family
cytochrome c oxidase subunit 2 family (according to Swiss-Prot)[SW|Cofactors]
Cu(A) [Pubmed|10837475]Structure
[PDB|2YEV] (from Thermus thermophilus, 35% identity) [pubmed|22763450][SW|Localization]
cell membrane [Pubmed|23880299]Expression and Regulation
Operons
genes
[gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]-[gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]-[gene|20D1174554A03EECE233A1A045F6DF83AF799959|ctaD]-[gene|9DF8423F1D63ED3928B2818F58BC3DECCDBB1DDB|ctaE]-[gene|28E5AF86CE49D7B0ECBFAF9ED5C1FC65D9F810EA|ctaF]-[gene|8C16E115CB59A74C24954BFCDE112720BA09D5EA|ctaG]
description
[Pubmed|9829923]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: activation, [Pubmed|9829923], in [regulon|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD regulon][protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|Abh]: repression, synergistic repression with [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB], in [regulon|5872812AB61E92E2944E926915EB7FEE71BFA6D5|Abh regulon][protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon][protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]: repression, synergistic repression with [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|Abh], in [regulon|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB regulon]regulation
expressed under anaerobic conditions ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]) [Pubmed|9829923]view in new tabBiological materials
Mutant
BKE14890 (Δ[gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCACCCAACCCCTTTT, downstream forward: _UP4_TAGGGAAGAAAGGGAGATATBKK14890 (Δ[gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14890 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCACCCAACCCCTTTT, downstream forward: _UP4_TAGGGAAGAAAGGGAGATATReferences
9882689,1685007,10551842,9829923,12850135,23599347,20817675,23880299,10837475,27503613,22763450