tagA [Mon Dec 14 2015 11:09:25 GMT+0100 (CET)]

UDP-N-acetyl-D-mannosamine transferase

Locus: BSU35750

Isoelectric point: 10.00

Molecular weight: 29.00 kDa

Function: biosynthesis of teichoic acid

Product: UDP-N-acetyl-D-mannosamine transferase

Essential: yes

E.C.: 2.4.1.187

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of teichoic acid
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of teichoic acid
• Groups of genes → Essential genes

Categories containing this gene/protein

• cell wall synthesis, biosynthesis of cell wall components

This gene is a member of the following regulons

• PhoP regulon, WalR regulon

Gene

Coordinates on the chromosome (coding sequence): 3,681,370 -> 3,682,140

Phenotypes of a mutant

• essential PubMed, reduced growth rate, loss of rod-like morphology PubMed
• inactivation of tagA strongly restores beta-lactam resistance in a sigM mutant PubMed

The protein

Catalyzed reaction/ biological activity

• UDP-N-acetyl-D-mannosamine N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol (according to Swiss-Prot)

Protein family

• glycosyltransferase 26 family (according to Swiss-Prot)

Localization

• secreted (according to Swiss-Prot)

Expression and Regulation

Operon

• tagA-tagB PubMed

Sigma factor

• SigA PubMed

Regulation

• repressed when phosphate is available (PhoP) PubMed

Regulatory mechanism

• PhoP: transcription repression PubMed
• WalR: transcription activation PubMed

References

Reviews

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Original publications

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